336 ΒC: Philip II murdered at Aegae. Alexander III (the Great) becomes king of Macedon (until 323 BC). First issues of silver tetradrachms
334 BC: Alexander crosses into Asia Minor, leaving Antipater as regent of Macedon. Gold and silver issues in Asia Minor.
333 BC: Alexander enters Cilicia and defeats Darius III at Issus.
332 BC: Alexander occupies Coele-Syria and Phoenicia and captures Tyre after a seven-month siege.
332/1 BC: Alexander winters in Egypt, founds Alexandria, and visits the oracle of Zeus Ammon in the oasis of Siwah.
331 BC: Alexander defeats Darius at Gaugamela and occupies Babylon and Susa.
330 BC: Alexander occupies Persepolis, capturing the Persian royal treasure. Darius, in flight from Alexander, is murdered by Bessus, satrap of Bactria.
330/29 BC: Alexander’s conquest of Bactria and Sogdiana.
327-325 BC: Alexander’s Indian expedition.
323 BC: Death of Alexander at Babylon.
323 BC: Posthumous gold and silver coin issues in the name of Alexander III.